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McNicholas WT – The pathophysiological and clinical significance of systemic inflammation in COPD and sleep apnea is not proven, and thus, studies of patients with the overlap syndrome should provide insight into the mechanisms of systemic inflammation in COPD and sleep apnea, in addition to potential relationships with cardiovascular disease.

Exclusive Author Commentary
Walter T McNicholas, 07/29/09

Because of the high prevalence of COPD and sleep apnea, the overlap of both disorders is common, affecting up to one percent of the adult population, and such patients are prone to severe nocturnal hypoxemia.

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