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Gupta RT et al. – The data appear to support the use of a quantitative D–dimer assay as a first–line test in evaluation for pulmonary embolism when the clinical probability of the presence of pulmonary embolism is low or intermediate. The sensitivity and negative predictive value were 100% for these cases. More than 26% of CT angiographic examinations might have been avoided if the D–dimer assay had been used as a first–line test in the care of patients at low or intermediate risk.

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