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See Latest ArticlesExposure-response relationship between lung cancer and polycyclic aromatic hydrocarbons (PAHs): Estimates from a large aluminium smelter cohort
Occupational and Environmental Medicine, 07/10/09
Armstrong BG et al. - Despite the large cohort with long follow-up, the shape of the exposure-response function and the mode of combination of risks due to occupational polycyclic aromatic hydrocarbons (PAH) and smoking remains uncertain for lung cancer.
Methods- Study to estimate the exposure-response function associating PAH exposure and lung cancer, with consideration of smoking
- Mortality, occupational exposure and smoking histories were ascertained for 16,431 persons (15703 men) who had worked in aluminium smelters
- In 677 lung cancer cases, increasing risk with increasing cumulative exposure to PAH was seen
- A linear model predicted a relative risk of 1.35 at 100 µg/m 3-BaP-yrs
- However, there was a significant departure from linearity in the direction of decreasing slope with increasing exposures
- Among the models tried, the best fitting were a 2-knot cubic spline and a power curve, the latter predicting a relative risk of 2.68 at 100 µg/m 3-BaP-yrs
- Additive models and multiplicative models for combining risks from occupational PAH and smoking fitted almost equally well, with a slight advantage to the additive
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