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The spectrum of structural abnormalities on CT scans from CF patients with severe advanced lung disease
Thorax, 07/08/09

Loeve M et al. - The authors developed a CT scoring system to characterize the structural abnormalities in patients with SALD. A wide spectrum was observed in SALD ranging from predominantly air trapping to predominantly infection/inflammation-related changes. This spectrum may have clinical implications for patients with SALD.

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Harm Tiddens, 07/08/09

This article shows clearly that in end stage lung disease a large volume of the lung is occupied by trapped air in addition to bronchiectasis. Trapped air reflects irreversible changes in the small airways. Hence, trapped air in early CF lung disease is not an innocent bystander but actually should be taken as seriously as bronchiectasis.

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