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See Latest ArticlesBleomycin induces pleural and subpleural fibrosis in the presence of carbon particles
European Respiratory Journal , 07/09/09
Decologne N et al. - This represents a novel approach to induce a robust experimental model of pleural fibrosis. It also suggests that carbon particles might be involved as a co-factor in the initiation and/or progression of (subpleural) pulmonary and pleural fibrosis. Mesothelial cells appear to be critical contributors to this fibrotic process.
P. Bonniaud, 07/11/09
| We demonstrate in this paper that the induction and progression of severe pleural and – even more important - subpleural fibrosis induced by bleomycin occurs only in the presence of carbon black particles. We show that this process involves EMT. This highlights a possibly important role of the mesothelium in pleural fibrosis but also in lung parenchyma pathology as IPF. |
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