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See Latest ArticlesDeterminants of Hypercapnia in Obese Patients With Obstructive Sleep Apnea
Chest, 07/07/09
Kaw R et al. - In obese patients with OSA and mostly without COPD, daytime hypercapnia was associated with severity of OSA, higher BMI levels, and degree of restrictive chest wall mechanics. A high index of suspicion should be maintained in patients with these factors, as early recognition and appropriate treatment can improve outcomes.
Roop Kaw, 07/13/09
| It is unclear which patients with OSA and without other contributing Lung disease will eventually become hypercapnic. Fortunately, the proportion of such patients amongst the obese with OSA is small. The precise pathophysiologic mechanisms that lead to hypercapnia in obese patients with OSA have not been worked out yet. These mechanisms seem to be likley related to ventilatory control. However, for busy practising clinicians it is important to suspect underlying hypercapnia in patients with higher severity of Obesity and related OSA and degree of impaired chest wall physiology even if they have no contributing lung disease. |
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