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See Latest ArticlesRNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease
Arthritis & Rheumatism, 07/14/09
Sato S et al. - Given that RNA helicase encoded by MDA-5 is a critical molecule involved in the innate immune defense against viruses, viral infection may play an important role in the pathogenesis of C-ADM and rapidly progressive ILD. Moreover, the ELISA using recombinant MDA-5 protein makes detection of the anti-CADM-140 antibody routinely available.
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