Pulmonology Medical News about Sarcomas

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Soft tissue sarcomas of the chest wall
Journal of Thoracic Oncology, 06/29/09

Tsukushi S et al. - The clinical behavior of the chest wall soft tissue sarcomas is similar to that of extremity sarcomas. High-grade tumors likely require a muscle transfer, and are difficult to control locally. They are best controlled by adequate wide surgical resection.

Methods

An evaluation of the clinical outcomes for pts with chest wall soft tissue sarcomas
44 surgically treated pts from 1992 to 2006; median age: 51.8 yrs; median follow-up: 56.7 mo
22 sarcomas (50.0%) were high-grade, and 22 (50.0%) were low-grade
Of the 44 pts, 31 (70.1%) had previously undergone unplanned excision elsewhere
Histologic examinations of the surgical margins, and oncological outcome for each patient were collected and analyzed

Results

26 (59.1%) pts were continuously free of disease, 12 were alive and currently free of disease, 3 were alive with metastasis, and 3 had died
Local recurrence developed in 5 pts
The overall survival rate at 5 yrs was 88.5%
Local recurrence-free survival rate at 5 yrs was 88.5%
Univariate analyses: age, high-grade malignancy, and local recurrence were independent predictors of death
Histopathologic examination: 2 pts had evidence of bone invasion

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