Pulmonology

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Soft tissue sarcomas of the chest wall
Journal of Thoracic Oncology, 06/29/09

Tsukushi S et al. - The clinical behavior of the chest wall soft tissue sarcomas is similar to that of extremity sarcomas. High-grade tumors likely require a muscle transfer, and are difficult to control locally. They are best controlled by adequate wide surgical resection.

• An evaluation of the clinical outcomes for pts with chest wall soft tissue sarcomas
• 44 surgically treated pts from 1992 to 2006; median age: 51.8 yrs; median follow-up: 56.7 mo
• 22 sarcomas (50.0%) were high-grade, and 22 (50.0%) were low-grade
• Of the 44 pts, 31 (70.1%) had previously undergone unplanned excision elsewhere
• Histologic examinations of the surgical margins, and oncological outcome for each patient were collected and analyzed

• 26 (59.1%) pts were continuously free of disease, 12 were alive and currently free of disease, 3 were alive with metastasis, and 3 had died
• Local recurrence developed in 5 pts
• The overall survival rate at 5 yrs was 88.5%
• Local recurrence-free survival rate at 5 yrs was 88.5%
• Univariate analyses: age, high-grade malignancy, and local recurrence were independent predictors of death
• Histopathologic examination: 2 pts had evidence of bone invasion

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