Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. EGFR inhibitors as first-line therapy in advanced non-small cell lung cancer
Your Article Summary
See Latest ArticlesWhy is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma
Immunology & Cell Biology, 06/24/09
Voelkel NF et al. - A molecular model of the pathobiology of asthma can be built by connecting hypoxia-inducible transcription factor-1 alpha, VEGF S1P, and bone-marrow precursor cell mobilization and acknowledging that angiogenesis is part of the inflammatory response.
Dr NF Voelkel, 06/24/09
| The message of this 'hypothesis paper' is that asthma is likely more than an airway disease. A modern view of chronic and progressive lung diseases departs from the concept of compartment restriction of the diseases. For example: interstitial fibrosis also involves the lung vessels and COPD is also a systemic disorder. Breaking down the compartment restriction the pathobiology can be investigated in its entirety and the systems biology approach will likely lead to new treatment strategies rather than to the development of just another bronchodilator for the treatment of asthma. |
Related Articles
Clinical importance of identifying immunoglobulin E-mediated disease in patients with Asthma
Clinical Cornerstone, 10/01/09
Relevance Score: 96%
Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma
Osteoporosis International, 10/13/09
Relevance Score: 95%
The Saudi Initiative for asthma
Annals of Thoracic Medicine, 10/13/09
Relevance Score: 95%
Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study
Journal of Allergy and Clinical Immunology, 10/09/09
Relevance Score: 95%
Identification of Asthma Phenotypes using Cluster Analysis in the Severe Asthma Research Program
American Journal of Respiratory and Critical Care Medicine, 11/09/09
Relevance Score: 94%
Today in Asthma/Atopy...keeping you current
Receive free subspecialty "5-minute updates" via email
Inhaled Corticosteroids Should Be Initiated Before Discharge from the Emergency Department in Patients with Persistent Asthma
Journal of Asthma, 12/15/09
Exhaled nitric oxide predicts control in patients with difficult-to-treat asthma
European Respiratory Journal , 12/15/09
Increased Fraction of Exhaled Nitric Oxide Predicts New-onset Wheeze in a General Population
American Journal of Respiratory and Critical Care Medicine, 12/15/09
Sponsor
Article Search
Sponsor
Sponsor