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Genetic Polymorphisms of the Serotonin Transporter, but Not the 2a Receptor or Nitric Oxide Synthetase, Are Associated with Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease
Respiration, 06/24/09

Ulrich S et al. - In this COPD cohort the authors confirm that PH is frequent and usually mild, but out of proportion in a subgroup. The authors found a significant association of the L-allelic variant of 5HTT with PH overall and especially in out-of-proportion PH. These findings may point towards a role of the serotonin system in COPD-PH and warrant further studies.

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