Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. EGFR inhibitors as first-line therapy in advanced non-small cell lung cancer
Your Article Summary
Natriuretic peptides in systemic sclerosis-related pulmonary arterial hypertension
Seminars in Arthritis and Rheumatism, 06/23/09
Dimitroulas T et al. – Study concludes that systemic sclerosis (SSc) patients, particularly those with pulmonary arterial hypertension (PAH), have a derangement of the neurohormonal system, which worsens with disease severity and disease progression. Natriuretic peptides (NP) seem to be suitable noninvasive biomarkers for SSc PAH patients in terms of screening, diagnostic evaluation, risk stratification, and response to therapy, and this merits prospective evaluation.
Methods- Review to examine the evidence for the physiologic, diagnostic, and prognostic role of NP in the context of SSc PAH
- Medline search for articles published between Jan 1999 and Dec 2008
- Keywords: natriuretic peptides, systemic sclerosis or scleroderma, and pulmonary arterial hypertension
- In pts with SSc PAH, NP levels increase in proportion to the extent of right ventricular dysfunction
- They correlate significantly with functional capacity and echocardiographic and hemodynamic parameters
- NP may also provide prognostic information beyond conventional risk markers
- However, their use has to be considered against the background of the parameters that may influence their concentration
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Polymorphisms in the CASPASE Genes and Survival in Patients With Early-Stage Non-Small-Cell Lung Cancer
Journal of Clinical Oncology, 10/16/09
Absence of inflammation and pneumonia during infection with non-pigmented Yersinia pestis reveals new role for the pgm locus in pathogenesis
Infection and Immunity, 10/30/09
Association and interaction analyses of eight genes under asthma linkage peaks
Allergy, 10/15/09
Today in CV/Thromboembolic...keeping you current
Receive free subspecialty "5-minute updates" via email
Is pulmonary arterial hypertension really a late complication of systemic sclerosis
Chest, 10/09/09
The Use of Sildenafil in Persistent Pulmonary Hypertension of the Newborn
American Journal of Perinatology, 10/28/09
Continuous Positive Airway Pressure vs. Pressure Support Ventilation in Acute Cardiogenic Pulmonary Edema: A Randomized Trial
The Journal of Emergency Medicine, 10/13/09
Sponsor
Article Search
Sponsor


See Latest Articles


