Pulmonology Medical News about dismal prognosis;lung adenocarcinomas;relapse-related molecular signature

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Tomida S et al. - In a study to to identify a relapse-related signature that allows selection of a group of adenocarcinoma pts with a high probability of relapse, it was found that relapse-related molecular signature represented by 82 probes (RRS-82) may be useful for identifying adenocarcinoma pts at very high risk for relapse, even those with cancer in the early stage.

Methods

Whole-genome expression profiles were analyzed in 117 lung adenocarcinoma samples using microarrays consisting of 41,000 probes.
A weighted voting classifier for identifying pts with a relapse-related signature was constructed with an approach that allowed no information leakage during each training step, using 10-fold cross-validation and 100 random partitioning procedures.

Results

RRS-82 was identified through genome-wide expression profiling analysis of a training set of 60 pts.
The robustness of RRS-82 in the selection of pts with a high probability of relapse was then validated with a completely blinded test set of 27 adenocarcinoma pts, showing a clear association of high-risk RRS-82 with very poor pt prognosis regardless of disease stage.
Discriminatory power of RRS-82 was further validated using 30 stage I pts who underwent surgery at a distinct period of time as well as with the Duke data set on a different platform.
Completely separate training and validation procedures using another data set also successfully confirmed the predictive power of the genes comprising RRS-82.

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