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Treatment of Acne with Oral Isotretinoin in Patients with Cystic Fibrosis
BMJ - Archives of Diseases in Childhood, 06/08/09

Perera E et al. - Adolescents with cystic fibrosis and acne can be treated with oral isotretinoin. Oral isotretinoin should be considered for adolescents with cystic fibrosis who have acne associated with scarring, acne not clearing with topical and antibiotic treatment, acne associated with depression, or severe cystic acne.

Exclusive Author Commentary
Roderic J Phillips , 06/09/09

We received a question about the relatively low daily dosing schedule (20-40 mg per day). This is the standard dosing used for most of the adolescents we treat with isotretinoin and was not reduced for this subset of patients who have cystic fibrosis. At these lower doses, side effects are usually insignificant and complete clearing still occurs in most patients in the same timeframe as on higher doses.

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