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Pre-emptive administration of high-dose fluticasone at the onset of URI reduced the frequency of clinician-initiated treatment with OC by 10 percentage points, with a relative reduction of 50%. In the FG, children received fewer days of albuterol, parents’ quality of life improved and symptoms were milder and shorter. However, use of pre-emptive high-dose fluticasone was associated with a reduced gain in height and weight; consequently the potential risks outweighed the identifi ed benefits.

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