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See Latest ArticlesDown Regulation of Insular Cortex Responses to Dyspnea and Pain in Asthma
American Journal of Respiratory and Critical Care Medicine, 06/03/09
von Leupoldt A et al. - The results suggest a down-regulation of affect-related insular cortex activity by the PAG during perceived dyspnea and pain in patients with asthma. This might represent a neuronal habituation mechanism reducing the affective unpleasantness of dyspnea in asthma, which generalizes to other unpleasant physiological sensations such as pain.
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