Pulmonology Medical News about pirfenidone

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Effect of food and antacids on the pharmacokinetics of pirfenidone in older healthy adults
Pulmonary Pharmacology and Therapeutics, 05/29/09

Rubino CM et al. - Coadministration with food decreased the rate and, to a lesser degree, the extent of pirfenidone absorption of absorption. Analysis of adverse events revealed a correlation between pirfenidone Cmax and the risk of gastrointestinal (GI) adverse events, suggesting that food may reduce the risk of certain adverse events associated with pirfenidone. Administration of pirfenidone with food has a modest effect on overall exposure but results in lower peak concentrations, which may improve tolerability.

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