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Defining Disease Modification in Chronic Obstructive Pulmonary Disease
COPD: Journal of Chronic Obstructive Pulmonary Disease, 06/03/09

Halpin DMG et al. - The proposed working definition of disease modification resulting from the group discussions was “an improvement in, or stabilization of, structural or functional parameters as a result of reduction in the rate of progression of these parameters which occurs whilst an intervention is applied and may persist even if the intervention is withdrawn”. According to this definition, pharmacologic interventions may be considered disease-modifying if they provide consistent and sustained improvements in structural and functional parameters. Smoking cessation and lung volume reduction surgery would both qualify as disease-modifying interventions.

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