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Adoptive T-Cell Therapy of a Lung Transplanted Patient with Severe CMV Disease and Resistance to Antiviral Therapy
American Journal of Transplantation, 05/22/09
Brestrich G et al. - The experimental data indicate that this could be the consequence of the late differentiated phenotype of the infused T cells and therefore their insufficient longevity in vivo. The report signifies the high therapeutic potential of adoptive immunotherapy in the treatment of SOT recipients when all other measures show no effect.
Gordon Brestrich, 05/25/09
| The adoptive transfer of specific T-cell lines was examined as a new treatment strategy for SOT recipients suffering from severe CMV infections with resistance to antiviral therapy. The approach led to a significant improvement of the clinical symptomes, however this effect was only transient. The experimental data indicate that this could be the consequence of the late differentiated phenotype of the infused T cells and therefore their insufficient longevity in vivo. The report signifies the high therapeutic potential of adoptive immunotherapy in the treatment of SOT recipients when all other measures show no effect. |
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