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Singh S - Inhaled anticholinergics increased risk of the composite end point, myocardial infarction, and cardiovascular death, but not stroke or all-cause death. Inhaled anticholinergics increased risk of the composite end point in the 5 long-term trials but not in the 12 short-term trials. This review concludes that in patients with chronic obstructive pulmonary disease, long-term use of inhaled anticholinergics increases risk of major cardiovascular events.

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