Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. EGFR inhibitors as first-line therapy in advanced non-small cell lung cancer
Your Article Summary
See Latest ArticlesA dose-finding and pharmacokinetic study of nedaplatin in elderly patients with advanced non-small cell lung cancer
Cancer Chemotherapy and Pharmacology, 04/29/09
Yamamoto N et al. - In a trial to determine the recommended dose, and evaluate the toxicities, pharmacokinetics, and efficacy for elderly non-small cell lung cancer (NSCLC) pts, it was found that nedaplatin was administered simply and feasibly by stratifying renal function and exerted favorable antitumor activity for elderly pts with NSCLC, especially on squamous cell carcinoma (SCC).
Methods- Pts ≥70 yrs were stratified into 2 groups based on renal functions: Group A, Ccr ≥60 and Group B, 40 ≤Ccr < 60.
- Initial doses were 80 and 60 mg/m2 in Groups A and B, respectively.
- Doses were escalated in 20-mg/m2 increments to 100 mg/m2 until DLT.
- Chemotherapy-naïve 39 elderly pts (Group A/Group B: 22/17) received 83 cycles.
- Major toxicities were hematological.
- In Group A, 1 of 15 pts at 100 mg/m2 experienced DLT (neutropenia) and the recommended dose was determined at 100 mg/m2.
- In Group B, 3 of 5 pts had DLTs (leukopenia, neutropenia, thrombocytopenia and febrile neutropenia) at 100 mg/m2, and the recommended dose was determined at 80 mg/m2.
- Percentage decreases of neutrophil were well correlated with total and free-Pt AUCs.
- Partial responses were observed in 13 (33%) of the 39 pts, and 12 of 13 pts who responded had SCC.
Today in Clinical Pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
A Randomized Trial of Nebulized 3% Hypertonic Saline With Epinephrine in the Treatment of Acute Bronchiolitis in the Emergency Department
Archives of Pediatrics and Adolescent Medicine, 11/23/09
An Umbrella Review: Corticosteroid Therapy for Adults with Acute Asthma
American Journal of Medicine, 10/27/09
Chronic Obstructive Pulmonary Disease: Role of Bacteria and Updated Guide to Antibacterial Selection in the Older Patient
Drugs & Aging, 11/25/09
Today in Lung/Thoracic Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Tumor necrosis factor inhibitors and lung disease: A paradox of efficacy and risk
Seminars in Arthritis and Rheumatism, 11/20/09
Randomized phase III trial of gemcitabine-based chemotherapy with in situ RRM1 and ERCC1 protein levels for response prediction in non-small-cell lung cancer
Journal of Clinical Oncology, 11/05/09
Is neoadjuvant chemoradiotherapy a feasible strategy for stage IIIA-N2 non-small cell lung cancer? Mature results of the randomized IFCT-0101 phase II trial
Lung Cancer, 11/03/09
Sponsor
Article Search
Sponsor