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Beryllium hypersensitivity and chronic beryllium lung disease
Current Opinion in Pulmonary Medicine, 02/26/09

Tomas S et al. - Lower occupational limit levels to beryllium exposure and more stringent preventive measures can decrease the risk for development of BeH and CBD. Beryllium sensitization is determined by a positive beryllium lymphocyte proliferation test (BeLPT). Longitudinal data suggest that BeH progresses to CBD. HLA-DPB1-Glu69 marker is associated with increased susceptibility to development of BeH and CBD but poor positive predictive value limits its use; other genetic markers are being investigated. Recent investigations augment the understanding on the role of T-lymphocytes and chemokines in the pathogenesis of beryllium-associated disease.

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