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Environmental Triggers and Susceptibility Factors in Idiopathic Granulomatous Diseases
Seminars in Respiratory and Critical Care Medicine, 02/23/09

Spagnolo P et al. - This approach proved to be fruitful in both sarcoidosis and Wegener granulomatosis, suggesting that stratification of data by clinical phenotypes may discover genetic associations that analysis of disease susceptibility alone would fail to detect. Unraveling how genetic risk factors and environmental triggers interact to determine the disease is challenging but will inevitably have an impact on both diagnostic and therapeutic strategies in granulomatous lung diseases.

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