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Khosravi N et al. - Large preterm infants are generally not considered good candidates for surfactant treatment until they have been intubated for progressing respiratory distress. There were no differences in the two groups for need of subsequent retreatment with surfactant and requirement for supplemental oxygen or mechanical ventilation, hospital stay and adverse outcomes. Results of this study indicate that elective intubation for administration of early single-dose surfactant to large preterm infants is not necessary.

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