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Epithelial cell [alpha]3[beta]1 integrin links [beta]-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
Journal of Clinical Investigation, 12/23/08
Kim KK et al. - The findings demonstrate epithelial integrin–dependent profibrotic crosstalk between [beta]-catenin and Smad signaling and support the hypothesis that EMT is an important contributor to pathologic fibrosis.
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