Proteomic identification of OprL as a seromarker for the initial diagnosis of Pseudomonas aeruginosa infection of patients with cystic fibrosis Rao AR et al. - Longitudinal Western blot analysis of sera from 12 of 14 patients with CF detected antibodies to OprL during the initial PA infection. In addition, antibodies were also detected to ExoS or ExoU or ExoS and ExoU, the latter implicating sequential PA infections during initial infections. Detection of serum reactivity to OprL, along with proteins of the TTSS, and in conjunction with microbiology may diagnose initial PA infections in patients with cystic fibrosis. [more...]
