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Pulmonology - Clinical Pharmacology News & Articles

Are you looking to stay current with all of the latest Pulmonology news articles and research? Look no further! MDLinx Pulmonology medical editors extensively research respiratory medical journals to find the most beneficial Pulmonology clinical literature. Topics range from: Pediatric Pulmonology, Sleep Disorders, Asthma, COPD, Cystic Fibrosis and much more. In a matter of minutes, Pulmonologists and their staff can stay up to date with the most current published information.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We also feature clinical pearls from our Internal Medicine Physician Review. You can also get the latest updates on salary information, search available Pulmonology jobs, view upcoming Pulmonology and CME conferences and earn some extra cash by participating in Market Research opportunities.

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Articles

Latest (2) Full Text Articles (212) Focus on Tuberculosis
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

121 Effects of Omalizumab in Non-Atopic Asthma Journal of Asthma, March 25, 2013    Clinical Article

122 Add-on omalizumab in children with severe allergic asthma: a one year real life survey European Respiratory Journal , March 25, 2013    Clinical Article

123 Use of tiotropium Respimat(R) SMI vs. tiotropium Handihaler(R) and mortality in patients with COPD European Respiratory Journal , March 25, 2013    Clinical Article

124 Acquisition of carbapenem resistance in multiresistant Klebsiella pneumoniae isolates of sequence type 11 at a university hospital in China Diagnostic Microbiology and Infectious Disease, March 25, 2013    Clinical Article

125 Metformin Enhances Cisplatin Cytotoxicity by Suppressing Stat3 Activity Independently of the LKB1-AMPK Pathway American Journal of Respiratory Cell and Molecular Biology, March 25, 2013    Clinical Article

126 A retrospective review of clinical features and treatment outcomes in steroid-resistant interstitial lung disease from polymyositis/dermatomyositis Respiratory Medicine, March 22, 2013    Review Article    Clinical Article

127 Focus on the potential role of ficlatuzumab in the treatment of non-small cell lung cancer Full Text Biologics: targets & therapy, March 21, 2013    Review Article

128 A Phase I Study of Pomalidomide (CC-4047) in Combination with Cisplatin and Etoposide in Patients with Extensive-Stage Small-Cell Lung Cancer Journal of Thoracic Oncology, March 20, 2013    Clinical Article

129 Efficacy of Icotinib for Advanced Non-small Cell Lung Cancer Patients with EGFR Status Identified Chinese Journal of Lung Cancer, March 20, 2013    Clinical Article

130 Sevoflurane suppresses tumour necrosis factor-{alpha}-induced inflammatory responses in small airway epithelial cells after anoxia/reoxygenation British Journal of Anesthesia, March 20, 2013    Clinical Article

131 Risk of Asthma Exacerbation, Asthma-Related Health Care Utilization and Costs, and Adherence to Controller Therapy in Patients with Asthma Receiving Fluticasone Propionate/Salmeterol Inhalation Powder 100µg/50µg Versus Mometasone Furoate Inhalation Powder Journal of Asthma, March 19, 2013    Clinical Article

132 Combination of budesonide/formoterol more effective than fluticasone/salmeterol in preventing exacerbations in chronic obstructive pulmonary disease. The PATHOS study Journal of Internal Medicine, March 19, 2013    Evidence Based Medicine    Clinical Article

133 COPD patient satisfaction with ipratropium bromide/albuterol delivered via Respimat: a randomized, controlled study Full Text International Journal of COPD, March 19, 2013    Clinical Article

134 Safety and efficacy of the once-daily anticholinergic BEA2180 compared with tiotropium in patients with COPD Respiratory Medicine, March 19, 2013    Clinical Article

135 The HLJ1-targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer Carcinogenesis, March 19, 2013    Clinical Article

136 Ten years of tiotropium: clinical impact and patient perspectives Full Text International Journal of COPD, March 18, 2013    Review Article    Clinical Article

137 Randomized Phase 2 Trial To Evaluate the Clinical Efficacy of Two High-Dosage Tigecycline Regimens versus Imipenem-Cilastatin for Treatment of Hospital-Acquired Pneumonia Antimicrobial Agents and Chemotherapy, March 18, 2013    Clinical Article

138 Cost-effectiveness of rifampin for 4months and isoniazid for 6months in the treatment of tuberculosis infection Respiratory Medicine, March 18, 2013    Clinical Article

139 Do oral corticosteroids reduce the severity of acute lower respiratory tract illnesses in preschool children with recurrent wheezing? The Journal of Allergy and Clinical Immunology, March 18, 2013    Clinical Article

140 Silibinin Synergizes with Histone Deacetylase and DNA Methyltransferase Inhibitors in Up-regulating E-cadherin Expression Together with Inhibition of Migration and Invasion of Human Non-small Cell Lung Cancer Cells Journal of Pharmacology and Experimental Therapeutics, March 18, 2013    Clinical Article

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Clinical Pearls in Pulmonology

Highlights in Pulmonology

Simvastatin has a modest effect on Streptococcus pneumoniae infections

Using a murine mouse model of pneumonia, prolonged simvastatin therapy has a measureable effect on Streptococcus pneumoniae infection, but no effect on mortality. Mice were treated with simvastatin (1 mg/kg/d [low dose] or 10 mg/kg/d [high dose]) for 4 weeks, then infected with S. pneumoniae intrathecally. Mice treated with the high-dose regimen had less lung consolidation, decreased macrophage and neutrophil infiltration, decreased MCP-1, KC, and ICAM-1 production, and decreased bacterial titers in the blood 36 and 42 h post-infection. Despite these favorable physiologic effects, there was no effect on mortality compared to control mice treated with ampicillin 48 h post-infection.

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Low D-dimer levels identify low-risk patients with community-acquired pneumonia

As published in the European Journal of Internal Medicine, there were no mortalities in patients with community-acquired pneumonia (CAP) and low levels of D-dimer (< 500 ug/l). Of 147 patients in the study, D-dimer levels were elevated in those with severe CAP (2166 vs. 1630 ug/l), day 30-clinical failure (2228 vs. 1594 ug/l), early failure (2499 vs. 1669 ug/l), and non-survivors (3025 vs. 1680 ug/l). Importantly, D-dimer levels were not shown to be associated with clinical outcome based on multivariate analysis.

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Bacteremia increases mortality risk in pneumococcal pneumonia

As published in the Journal of Infection, 114 of 981 (11.6%) of patients with pneumococcal pneumonia were bacteremic. Risk factors for bacteremia included immunosuppressants, age < 65 years, and diabetes mellitus. Patients with pneumococcal pneumonia and bacteria were at increased risk for mortality (28.6% vs. 8.5%). The combination of bacteremia, cerebrovascular disease, and septic shock had a strong association with mortality in patients with pneumococcal pneumonia.

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Most Popular Pulmonology Articles

Last month's top read Top Articles of 2012

1 High-Dose N-Acetylcysteine in the Prevention of COPD Exacerbations: Rationale and Design of the PANTHEON Study COPD: Journal of Chronic Obstructive Pulmonary Disease, April 9, 2013

2 Inhaled Corticosteroids in Lung Diseases American Journal of Respiratory and Critical Care Medicine, April 18, 2013

3 Feasibility of adding everolimus to carboplatin and paclitaxel, with or without bevacizumab, for treatment-naive, advanced non-small cell lung cancer Investigational New Drugs, April 12, 2013

4 Novel Functional Imaging of Changes in Small Airways of Patients Treated with Extrafine Beclomethasone/Formoterol Respiration, April 12, 2013

5 Regular treatment with salmeterol and inhaled steroids for chronic asthma: serious adverse events Cochrane Reviews, April 2, 2013    Review Article

6 Impact of intranasal corticosteroids on asthma outcomes in allergic rhinitis: a meta-analysis Allergy, April 19, 2013

7 Ten years of tiotropium: clinical impact and patient perspectives International Journal of COPD, March 18, 2013    Free full text    Review Article

8 Asthma medication delivery: Mists and myths Paediatric Respiratory Reviews, April 12, 2013

9 Effects of Omalizumab in Non-Atopic Asthma Journal of Asthma, March 25, 2013

10 Review: inhaled anticholinergics increase risk of major cardiovascular events in COPD Evidence-Based Medicine, May 8, 2009

11 Indacaterol on dyspnea in chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized placebo-controlled trials BMC Pulmonary Medicine, April 26, 2013    Free full text    Evidence Based Medicine    Review Article

12 Leukotriene Inhibitor Warning JAMA, July 23, 2009

13 Statin treatment and the risk of recurrent pulmonary embolism European Heart Journal, February 28, 2013

14 A phase I trial of pan-Bcl-2 antagonist obatoclax administered as a 3-h or a 24-h infusion in combination with carboplatin and etoposide in patients with extensive-stage small cell lung cancer British Journal of Cancer, February 15, 2012

15 Use of dexamethasone and prednisone in acute asthma exacerbations in pediatric patients Canadian Family Physician, July 16, 2009    Free full text
Exclusive Author Commentary

16 Phase III study of pemetrexed plus carboplatin compared with etoposide plus carboplatin in chemotherapy-naive patients with extensive-stage small-cell lung cancer Journal of Clinical Oncology, September 4, 2009    Free full text

17 Efficacy of Corticosteroid Therapy in Severe Decompensation of Chronic Obstructive Pulmonary Disease Requiring Mechanical Ventilation American Journal of Therapeutics, February 1, 2013

18 Promising therapeutic effects of sodium tanshinone IIA sulfonate towards pulmonary arterial hypertension in patients Journal of Thoracic Disease, April 3, 2013    Free full text

19 Developmental Current and Future Therapy for Severe Asthma Inflammation & Allergy - Drug Targets, April 8, 2013

20 Addition of Theophylline or Increasing the Dose of Inhaled Corticosteroid in Symptomatic Asthma: A Meta-Analysis of Randomized Controlled Trials Yonsei Medical Journal, February 22, 2011    Free full text    Evidence Based Medicine

Indexed Journals in Pulmonology: Chest, Thorax, American Journal of Respiratory and Critical Care Medicinemore

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