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Pulmonology - Basic Science/Genetics News & Articles
Are you looking to stay current with all of the latest Pulmonology news articles and research? Look no further! MDLinx Pulmonology medical editors extensively research respiratory medical journals to find the most beneficial Pulmonology clinical literature. Topics range from: Pediatric Pulmonology, Sleep Disorders, Asthma, COPD, Cystic Fibrosis and much more. In a matter of minutes, Pulmonologists and their staff can stay up to date with the most current published information.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We also feature clinical pearls from our Internal Medicine Physician Review. You can also get the latest updates on salary information, search available Pulmonology jobs, view upcoming Pulmonology and CME conferences and earn some extra cash by participating in Market Research opportunities.
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Your Unread Messages in Pulmonology
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Articles
Latest (1) Full Text Articles (147) Focus on Pneumonia981 Human Bronchial Epithelial Cells Differentiate to 3D Glandular Acini on Basement Membrane Matrix American Journal of Respiratory Cell and Molecular Biology, August 24, 2010
982 Lack of Cftr in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyper-inflammatory Adaptive Immune Responses American Journal of Respiratory Cell and Molecular Biology, August 24, 2010
983 Reactive oxygen species are involved in regulating alpha1-adrenoceptor-activated vascular smooth muscle contraction Journal of Biomedical Science, August 24, 2010
984 Systemic and exhaled cytokine and chemokine profiles are associated with the development of bronchiolitis obliterans syndrome The Journal of Heart and Lung Transplantation, August 24, 2010
985 Expression of soluble Toll-like receptors in pleural effusions Full Text Chinese Medical Journal, August 24, 2010
986 Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features Full Text Chinese Medical Journal, August 24, 2010
987 Bactericidal activity of the diarylquinoline TMC207 against Mycobacterium tuberculosis outside and within cells Tuberculosis , August 24, 2010
988 The alpha-4-beta-1 Integrin in Localization of Mycobacterium Tuberculosis-specific Th1 Cells to the Human Lung American Journal of Respiratory Cell and Molecular Biology, August 23, 2010
989 Expression of IL-4/IL-13 Receptors in Differentiating Human Airway Epithelial Cells The American Journal of Physiology - Lung Cellular and Molecular Physiology, August 23, 2010
990 Atrial natriuretic peptide attenuates LPS-induced lung vascular leak: role of PAK1 The American Journal of Physiology - Lung Cellular and Molecular Physiology, August 23, 2010
991 Serum Igf-I, Igf-Ii, Igfbp-3, And Igf-I/igfbp-3 Molar Ratio And Risk Of Pancreatic Cancer In The Prostate, Lung, Colorectal, And Ovarian Cancer Screening Trial Cancer Epidemiology, Biomarkers & Prevention, August 23, 2010
992 Epithelial-Mesenchymal Transition in EGFR-TKI Acquired Resistant Lung Adenocarcinoma Anticancer Research, August 23, 2010
993 Atypical expression and distribution of embryonic stem cell marker, OCT4, in human lung adenocarcinoma Journal of Surgical Oncology, August 20, 2010
994 Roles for Soluble Guanylate Cyclase and a Thiol Oxidation-Elicited Subunit Dimerization of Protein Kinase G in Pulmonary Artery Relaxation to Hydrogen Peroxide American Journal of Physiology - Heart and Circulatory Physiology, August 20, 2010
995 High molecular weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness The American Journal of Physiology - Lung Cellular and Molecular Physiology, August 19, 2010
996 Lane-Hamilton syndrome: ferritin protects lung macrophages against iron and oxidation Full Text Chest, August 18, 2010
997 The Effect of Class II Transactivator (CIITA) Mutations on Bleomycin Induced Lung Inflammation and Fibrosis American Journal of Respiratory Cell and Molecular Biology, August 17, 2010
998 Asthmatic Airway Epithelium is Intrinsically Inflammatory and Mitotically Dyssynchronous American Journal of Respiratory Cell and Molecular Biology, August 17, 2010
999 Dense-body aggregates as plastic structures supporting tension in smooth muscle cells The American Journal of Physiology - Lung Cellular and Molecular Physiology, August 17, 2010
1000 DNA damage and repair activity after broccoli intake in young healthy smokers Mutagenesis, August 17, 2010 Clinical Article
Clinical Pearls in Pulmonology
- Chloral hydrate is a sedative that might be used to promote sleep in your pediatric migraine patients.
- Along with cough variant asthma and nasal disease, gastroesophageal reflux is considered one of three main causes of chronic cough.
- Trazodone does not improve sleep for methadone-maintained persons with sleep disturbance.
Highlights in Pulmonology
Simvastatin has a modest effect on Streptococcus pneumoniae infections
Using a murine mouse model of pneumonia, prolonged simvastatin therapy has a measureable effect on Streptococcus pneumoniae infection, but no effect on mortality. Mice were treated with simvastatin (1 mg/kg/d [low dose] or 10 mg/kg/d [high dose]) for 4 weeks, then infected with S. pneumoniae intrathecally. Mice treated with the high-dose regimen had less lung consolidation, decreased macrophage and neutrophil infiltration, decreased MCP-1, KC, and ICAM-1 production, and decreased bacterial titers in the blood 36 and 42 h post-infection. Despite these favorable physiologic effects, there was no effect on mortality compared to control mice treated with ampicillin 48 h post-infection.
Read the article summaryLow D-dimer levels identify low-risk patients with community-acquired pneumonia
As published in the European Journal of Internal Medicine, there were no mortalities in patients with community-acquired pneumonia (CAP) and low levels of D-dimer (< 500 ug/l). Of 147 patients in the study, D-dimer levels were elevated in those with severe CAP (2166 vs. 1630 ug/l), day 30-clinical failure (2228 vs. 1594 ug/l), early failure (2499 vs. 1669 ug/l), and non-survivors (3025 vs. 1680 ug/l). Importantly, D-dimer levels were not shown to be associated with clinical outcome based on multivariate analysis.
Read the article summaryBacteremia increases mortality risk in pneumococcal pneumonia
As published in the Journal of Infection, 114 of 981 (11.6%) of patients with pneumococcal pneumonia were bacteremic. Risk factors for bacteremia included immunosuppressants, age < 65 years, and diabetes mellitus. Patients with pneumococcal pneumonia and bacteria were at increased risk for mortality (28.6% vs. 8.5%). The combination of bacteremia, cerebrovascular disease, and septic shock had a strong association with mortality in patients with pneumococcal pneumonia.
Read the article summaryMost Popular Pulmonology Articles
Last month's top read Top Articles of 20121 Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies British Medical Journal, April 10, 2013 Free full text
2 Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study Thorax, April 22, 2013
3 Biomarkers of disease: cerebrospinal fluid vascular endothelial growth factor (VEGF) and stromal cell derived factor (SDF)-1 levels in patients with neoplastic meningitis (NM) due to breast cancer, lung cancer and melanoma Journal of Neuro-Oncology, March 19, 2009
4 Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Central Lung Parenchymal Lesions Yonsei Medical Journal, April 11, 2013 Free full text
5 STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis Arthritis & Rheumatism, August 5, 2009
6 EGFR/KRAS/BRAF Mutations in Primary Lung Adenocarcinomas and Corresponding Locoregional Lymph Node Metastases Clinical Cancer Research, July 17, 2009 Free full text
7 Prognostic gene signatures for non-small cell lung cancer Proceedings of the National Academy of Sciences of the United States of America, February 25, 2009 Free full text
8 Isolation of fibroblasts and epithelial cells in Bronchoalveolar Lavage (BAL) Experimental Lung Research, April 2, 2013
9 A review of current and novel therapies for idiopathic pulmonary fibrosis Journal of Thoracic Disease, January 23, 2013 Free full text Review Article
10 Interstitial lung disease European Respiratory Review, March 12, 2013 Review Article
11 Genotyping of Mycobacterium intracellulare isolates and clinical characteristics of lung disease The International Journal of Tuberculosis and Lung Disease, April 8, 2013
12 Genetic variants and risk of lung cancer in never smokers: A genome-wide association study The Lancet Oncology, March 22, 2010
13 MUC5AC & inflammatory mediators associated with respiratory outcomes in the British 1946 birth cohort Respirology, April 5, 2013
14 Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer The Lancet Oncology, November 10, 2008
15 Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer Journal of Carcinogenesis, March 12, 2009 Free full text
16 Corticosteroids for prevention of mortality in people with tuberculosis: a systematic review and meta-analysis The Lancet, March 12, 2013 Evidence Based Medicine Review Article
17 Plasma Angiopoietin-2 Predicts the Onset of Acute Lung Injury in Critically Ill Patients American Journal of Respiratory and Critical Care Medicine, April 12, 2013
18 Regular treatment with salmeterol and inhaled steroids for chronic asthma: serious adverse events Cochrane Reviews, April 2, 2013 Review Article
19 Recent advances in the genetics of sarcoidosis Journal of Medical Genetics, April 15, 2013 Review Article
20 COPD Phenotypes: The Future of COPD American Journal of Respiratory and Critical Care Medicine, June 4, 2010 Free full text
Indexed Journals in Pulmonology: Chest, Thorax, American Journal of Respiratory and Critical Care Medicine more
Other Topics in Pulmonology
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