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Pulmonology - Basic Science/Genetics News & Articles
Are you looking to stay current with all of the latest Pulmonology news articles and research? Look no further! MDLinx Pulmonology medical editors extensively research respiratory medical journals to find the most beneficial Pulmonology clinical literature. Topics range from: Pediatric Pulmonology, Sleep Disorders, Asthma, COPD, Cystic Fibrosis and much more. In a matter of minutes, Pulmonologists and their staff can stay up to date with the most current published information.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We also feature clinical pearls from our Internal Medicine Physician Review. You can also get the latest updates on salary information, search available Pulmonology jobs, view upcoming Pulmonology and CME conferences and earn some extra cash by participating in Market Research opportunities.
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Your Unread Messages in Pulmonology
See All >> Messages include industry-sponsored communications and special communications from MDLinx-
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D Scott Cunningham MD, PhD
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ASA reduces risk of ACS in hospitalized pneumonia patients -
Articles
Latest (1) Full Text Articles (147) Focus on Sarcoidosis61 Radiotherapy for a second primary lung cancer arising post-pneumonectomy: planning considerations and clinical outcomes Full Text Journal of Thoracic Disease, April 4, 2013 Review Article
62 KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach Full Text Translational Lung Cancer Research, April 4, 2013 Review Article
63 Hypersensitivity reactions to carboplatin and cisplatin in non-small cell lung cancer Full Text Journal of Thoracic Disease, April 4, 2013
64 Hedgehog signaling pathway: the must, the maybe and the unknown Full Text Journal of Thoracic Disease, April 4, 2013 Clinical Article
65 Early-stage thymic carcinoma: is adjuvant therapy required? Full Text Journal of Thoracic Disease, April 4, 2013
66 Postoperative radiotherapy for residual tumor of primary mediastinal carcinoid teratoma Full Text Journal of Thoracic Disease, April 4, 2013
67 Regular treatment with salmeterol and inhaled steroids for chronic asthma: serious adverse events Cochrane Reviews, April 2, 2013 Review Article
68
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
The Journal of Allergy and Clinical Immunology, April 2, 2013
Review Article
Exclusive Author Commentary
69 Isolation of fibroblasts and epithelial cells in Bronchoalveolar Lavage (BAL) Experimental Lung Research, April 2, 2013 Clinical Article
70 Multiple isoforms and differential allelic expression of CHRNA5 in lung tissue and lung adenocarcinoma Carcinogenesis, April 1, 2013 Clinical Article
71 ERK phosphorylation is predictive of resistance to IGF-1R inhibition in small cell lung cancer Molecular Cancer Therapeutics, April 1, 2013 Clinical Article
72 Pleural Mesothelial Cell Differentiation and Invasion in Fibrogenic Lung Injury American Journal of Pathology, March 29, 2013 Review Article
73 Radiation-Induced Lung Injury Is Mitigated by Blockade of Gastrin-Releasing Peptide American Journal of Pathology, March 29, 2013 Review Article
74 Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies Full Text Respiratory Research, March 29, 2013 Clinical Article
75 FGFR4 genetic polymorphisms determine the chemotherapy response of Chinese patients with non-small cell lung cancer Acta Pharmacologica Sinica, March 29, 2013 Clinical Article
76 Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development Full Text BMC Pulmonary Medicine, March 29, 2013 Clinical Article
77 Inhibitory Effect of Mitomycin C on Proliferation of Primary Cultured Fibroblasts from Human Airway Granulation Tissues Respiration, March 28, 2013 Clinical Article
78 CXCL13 Production in B cells via TLR/Lymphotoxin Receptor Signaling are Involved in Lymphoid Neogenesis in COPD American Journal of Respiratory and Critical Care Medicine, March 25, 2013 Clinical Article
79 Bile acids increase alveolar epithelial permeability via MAP kinase, cytosolic phospholipase A2, cyclooxygenase-2, PGE2 and junctional proteins Respirology, March 25, 2013 Clinical Article
80 Alpha-1 Antitrypsin Modulates Lung Endothelial Cell Inflammatory Responses to TNF{alpha} American Journal of Respiratory Cell and Molecular Biology, March 25, 2013 Clinical Article
Clinical Pearls in Pulmonology
- Chloral hydrate is a sedative that might be used to promote sleep in your pediatric migraine patients.
- Along with cough variant asthma and nasal disease, gastroesophageal reflux is considered one of three main causes of chronic cough.
- Trazodone does not improve sleep for methadone-maintained persons with sleep disturbance.
Highlights in Pulmonology
Simvastatin has a modest effect on Streptococcus pneumoniae infections
Using a murine mouse model of pneumonia, prolonged simvastatin therapy has a measureable effect on Streptococcus pneumoniae infection, but no effect on mortality. Mice were treated with simvastatin (1 mg/kg/d [low dose] or 10 mg/kg/d [high dose]) for 4 weeks, then infected with S. pneumoniae intrathecally. Mice treated with the high-dose regimen had less lung consolidation, decreased macrophage and neutrophil infiltration, decreased MCP-1, KC, and ICAM-1 production, and decreased bacterial titers in the blood 36 and 42 h post-infection. Despite these favorable physiologic effects, there was no effect on mortality compared to control mice treated with ampicillin 48 h post-infection.
Read the article summaryLow D-dimer levels identify low-risk patients with community-acquired pneumonia
As published in the European Journal of Internal Medicine, there were no mortalities in patients with community-acquired pneumonia (CAP) and low levels of D-dimer (< 500 ug/l). Of 147 patients in the study, D-dimer levels were elevated in those with severe CAP (2166 vs. 1630 ug/l), day 30-clinical failure (2228 vs. 1594 ug/l), early failure (2499 vs. 1669 ug/l), and non-survivors (3025 vs. 1680 ug/l). Importantly, D-dimer levels were not shown to be associated with clinical outcome based on multivariate analysis.
Read the article summaryBacteremia increases mortality risk in pneumococcal pneumonia
As published in the Journal of Infection, 114 of 981 (11.6%) of patients with pneumococcal pneumonia were bacteremic. Risk factors for bacteremia included immunosuppressants, age < 65 years, and diabetes mellitus. Patients with pneumococcal pneumonia and bacteria were at increased risk for mortality (28.6% vs. 8.5%). The combination of bacteremia, cerebrovascular disease, and septic shock had a strong association with mortality in patients with pneumococcal pneumonia.
Read the article summaryMost Popular Pulmonology Articles
Last month's top read Top Articles of 20121 Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies British Medical Journal, April 10, 2013 Free full text
2 Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study Thorax, April 22, 2013
3 Biomarkers of disease: cerebrospinal fluid vascular endothelial growth factor (VEGF) and stromal cell derived factor (SDF)-1 levels in patients with neoplastic meningitis (NM) due to breast cancer, lung cancer and melanoma Journal of Neuro-Oncology, March 19, 2009
4 Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Central Lung Parenchymal Lesions Yonsei Medical Journal, April 11, 2013 Free full text
5 STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis Arthritis & Rheumatism, August 5, 2009
6 EGFR/KRAS/BRAF Mutations in Primary Lung Adenocarcinomas and Corresponding Locoregional Lymph Node Metastases Clinical Cancer Research, July 17, 2009 Free full text
7 Prognostic gene signatures for non-small cell lung cancer Proceedings of the National Academy of Sciences of the United States of America, February 25, 2009 Free full text
8 Isolation of fibroblasts and epithelial cells in Bronchoalveolar Lavage (BAL) Experimental Lung Research, April 2, 2013
9 A review of current and novel therapies for idiopathic pulmonary fibrosis Journal of Thoracic Disease, January 23, 2013 Free full text Review Article
10 Interstitial lung disease European Respiratory Review, March 12, 2013 Review Article
11 Genotyping of Mycobacterium intracellulare isolates and clinical characteristics of lung disease The International Journal of Tuberculosis and Lung Disease, April 8, 2013
12 Genetic variants and risk of lung cancer in never smokers: A genome-wide association study The Lancet Oncology, March 22, 2010
13 MUC5AC & inflammatory mediators associated with respiratory outcomes in the British 1946 birth cohort Respirology, April 5, 2013
14 Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer The Lancet Oncology, November 10, 2008
15 Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer Journal of Carcinogenesis, March 12, 2009 Free full text
16 Corticosteroids for prevention of mortality in people with tuberculosis: a systematic review and meta-analysis The Lancet, March 12, 2013 Evidence Based Medicine Review Article
17 Plasma Angiopoietin-2 Predicts the Onset of Acute Lung Injury in Critically Ill Patients American Journal of Respiratory and Critical Care Medicine, April 12, 2013
18 Regular treatment with salmeterol and inhaled steroids for chronic asthma: serious adverse events Cochrane Reviews, April 2, 2013 Review Article
19 Recent advances in the genetics of sarcoidosis Journal of Medical Genetics, April 15, 2013 Review Article
20 COPD Phenotypes: The Future of COPD American Journal of Respiratory and Critical Care Medicine, June 4, 2010 Free full text
Indexed Journals in Pulmonology: Chest, Thorax, American Journal of Respiratory and Critical Care Medicine more
Other Topics in Pulmonology
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