Pulmonology News Articles ▼ Show details

Stay current with the latest Pulmonology news articles and research. MDLinx pulmonary medical editors extensively research respiratory journals to find the most beneficial pulmonary clinical literature. Topics range from: Pediatric Pulmonology, Sleep Disorders, Asthma, COPD, ARDS, Cystic Fibrosis and much more. In a matter of minutes, Pulmonologists and their staff can stay current with the latest published news and information in Pulmonology.

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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Efficacy and safety of maintenance pemetrexed in patients with advanced nonsquamous non-small cell lung cancer following pemetrexed plus cisplatin induction treatment: a cross-trial comparison of two phase III trials Lung Cancer, July 22, 2014    Clinical Article

2 Randomized study of the safety, pharmacokinetics, and bronchodilatory efficacy of a proprietary glycopyrronium metered-dose inhaler in study patients with chronic obstructive pulmonary disease Full Text BMC Pulmonary Medicine, July 22, 2014    Clinical Article

3 Increased whole body hydroxyproline production as assessed by a new stable isotope technique is associated with hip and spine bone mineral loss in cystic fibrosis Clinical Nutrition, July 22, 2014    Clinical Article

4 Is C-reactive protein testing useful to predict outcome in patients with acute bronchitis? Family Practice, July 22, 2014    Clinical Article

5 Body mass index in lung transplant candidates: A contra-indication to transplant or not? Transplantation Proceedings, July 22, 2014    Clinical Article

6 Gender susceptibility for cigarette smoking-attributable lung cancer: a systematic review and meta-analysis Lung Cancer, July 22, 2014    Evidence Based Medicine    Review Article

7 Efficacy and safety of pemetrexed/cisplatin versus gemcitabine/cisplatin as first-line treatment in Chinese patients with advanced nonsquamous non-small cell lung cancer Lung Cancer, July 22, 2014    Clinical Article

8 An intelligent system for lung cancer diagnosis using a new genetic algorithm based feature selection method Journal of Medical Systems, July 22, 2014    Clinical Article

9 Long-term smoking increases the need for acute care among asthma patients: A case control study Full Text BMC Pulmonary Medicine, July 22, 2014    Clinical Article

10 Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease Full Text BMC Cancer, July 22, 2014    Clinical Article

11 Emerging role of microRNAs and long noncoding RNAs in respiratory disease Chest, July 22, 2014    Review Article

12 Alemtuzumab in lung transplantation: an open-label, randomized, prospective single center study American Journal of Transplantation, July 22, 2014    Clinical Article

13 The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections: A randomized trial American Journal of Respiratory and Critical Care Medicine, July 22, 2014    Clinical Article

14 Osteoporosis in the at-risk asthmatic Allergy, July 22, 2014    Clinical Article

15 Clinical equivalence of budesonide dry powder inhaler and pressurized metered dose inhaler The Clinical Respiratory Journal, July 22, 2014    Clinical Article

16 Role of interventional pulmonology in the management of complicated parapneumonic pleural effusions and empyema Respirology, July 22, 2014    Clinical Article

17 SPARC/osteonectin is involved in metastatic process to the lung during melanoma progression Virchows Archiv, July 22, 2014    Clinical Article

18 Sublobar resection for early-stage lung cancer Full Text Translational Lung Cancer Research, July 22, 2014    Review Article

19 Correlation between EGFR mutation status and response to first-line platinum-based chemotherapy in patients with advanced non-small cell lung cancer Full Text OncoTargets and Therapy, July 22, 2014    Clinical Article

20 IL-6 augments lung cancer chemotherapeutics resistance via ATM/NF-kappaB pathway activation Cancer Science, July 22, 2014    Clinical Article

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Highlights in Pulmonology

Simvastatin has a modest effect on Streptococcus pneumoniae infections

Using a murine mouse model of pneumonia, prolonged simvastatin therapy has a measureable effect on Streptococcus pneumoniae infection, but no effect on mortality. Mice were treated with simvastatin (1 mg/kg/d [low dose] or 10 mg/kg/d [high dose]) for 4 weeks, then infected with S. pneumoniae intrathecally. Mice treated with the high-dose regimen had less lung consolidation, decreased macrophage and neutrophil infiltration, decreased MCP-1, KC, and ICAM-1 production, and decreased bacterial titers in the blood 36 and 42 h post-infection. Despite these favorable physiologic effects, there was no effect on mortality compared to control mice treated with ampicillin 48 h post-infection.

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Low D-dimer levels identify low-risk patients with community-acquired pneumonia

As published in the European Journal of Internal Medicine, there were no mortalities in patients with community-acquired pneumonia (CAP) and low levels of D-dimer (< 500 ug/l). Of 147 patients in the study, D-dimer levels were elevated in those with severe CAP (2166 vs. 1630 ug/l), day 30-clinical failure (2228 vs. 1594 ug/l), early failure (2499 vs. 1669 ug/l), and non-survivors (3025 vs. 1680 ug/l). Importantly, D-dimer levels were not shown to be associated with clinical outcome based on multivariate analysis.

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Bacteremia increases mortality risk in pneumococcal pneumonia

As published in the Journal of Infection, 114 of 981 (11.6%) of patients with pneumococcal pneumonia were bacteremic. Risk factors for bacteremia included immunosuppressants, age < 65 years, and diabetes mellitus. Patients with pneumococcal pneumonia and bacteria were at increased risk for mortality (28.6% vs. 8.5%). The combination of bacteremia, cerebrovascular disease, and septic shock had a strong association with mortality in patients with pneumococcal pneumonia.

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Other Topics in Pulmonology

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