18FDG-PET/CT for detection of mediastinal nodal metastasis in non-small cell lung cancer: A meta-analysis
Surgical Oncology, 08/09/2012
Evidence Based Medicine
Zhao L et al. – 18F–fluorodeoxyglucos –e positron emission tomography/computed tomography (18FDG–PET/CT) had more specificity but less sensitivity for mediastinal nodal metastasis in patients with non–small cell lung cancer (NSCLC).Methods
- Studies about 18FDG-PET/CT for detecting mediastinal nodal metastasis in patient with NSCLC were systematically searched in the MEDLINE, EMBASE, and EBM Review databases from January 1, 2000 to July 26, 2011.
- A software called “Meta-Disc” was used to obtain pooled estimates of sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR), respectively.
- The authors also calculated summary receiver operating characteristic (SROC) curves, and the Q* index.
- 20 articles fufilled all inclusion criteria (3028 eligible patients).
- The pooled sensitivity, and specificity with 95% confidence interval for PET/CT on a per-patient analysis were 0.719 (0.683–0.753), and 0.898 (0.882–0.912).
- Corresponding values for PET/CT on a per-nodal-station analysis were 0.610 (0.582–0.636), 0.924 (0.918–0.930).
- The Q* index estimates under SROC were 0.8464 and 0.8067, respectively.