Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas
Modern Pathology, 07/11/2012
Nishino M et al. – Anaplastic lymphoma receptor tyrosine kinase (ALK)+lung adenocarcinomas have distinctive morphologic features, with signet ring cells showing a significant association with ALK rearrangements irrespective of tumor site (primary vs metastatic) or specimen type. However, morphologic screening alone will not detect a minority of ALK+ lung adenocarcinomas, and the routine use of ancillary studies may be warranted to identify all patients who may benefit from crizotinib treatment.