Sildenafil for Chronic Obstructive Pulmonary Disease: A Randomized Crossover Trial
COPD: Journal of Chronic Obstructive Pulmonary Disease,  Clinical Article

Lederer DJ et al. – Routine sildenafil administration did not have a beneficial effect on exercise capacity in patients with chronic obstructive pulmonary disease (COPD) and emphysema without pulmonary hypertension. Sildenafil significantly worsened gas exchange at rest and quality of life.

Methods
  • The authors performed a randomized, double–blind, placebo–controlled 2–period crossover trial of sildenafil thrice daily in ten adults with COPD and emphysema on CT scan without pulmonary hypertension.
  • The authors randomized study participants to 4 weeks of sildenafil (or placebo) followed by a 1–week washout and then 4 weeks of placebo (or sildenafil).
  • The 2 primary outcomes were the 6–minute walk distance and oxygen consumption at peak exercise.

Results
  • Sildenafil had no effect on 6–minute walk distance (placebo–corrected difference = –7.8 m, 95% confidence interval, –23.2 to 7.5 m, p = 0.35) or oxygen consumption at peak exercise (placebo–corrected difference = –0.1 ml/kg/min, 95% confidence interval –2.1 to 1.8 ml/kg/min, p = 0.89).
  • Sildenafil increased the alveolar–arterial oxygen gradient (p = 0.02), worsened symptoms (p = 0.04), and decreased quality–of–life (p = 0.03).
  • Adverse events were more frequent while receiving sildenafil (p = 0.005).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pulmonology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pulmonology Articles

1 Azithromycin maintenance treatment in patients with frequent exacerbations of chronic obstructive pulmonary disease (COLUMBUS): A randomised, double-blind, placebo-controlled trial The Lancet Respiratory Medicine, May 15, 2014    Clinical Article

2 Value of different bronchoscopic sampling techniques in diagnosis of sarcoidosis: A prospective study of 151 patients Journal of Bronchology & Interventional Pulmonology, July 21, 2014    Clinical Article

3 Effects of yoga training in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis Full Text Journal of Thoracic Disease, July 7, 2014    Free full text    Evidence Based Medicine

4 Serial chitotriosidase measurements in sarcoidosis - Two to five year follow-up study Respiratory Medicine, May 30, 2014    Clinical Article

5 Tadalafil in patients with chronic obstructive pulmonary disease: a randomised, double-blind, parallel-group, placebo-controlled trial The Lancet Respiratory Medicine, March 6, 2014    Clinical Article

6 Association of azithromycin with mortality and cardiovascular events among older patients hospitalized with pneumonia JAMA, June 4, 2014    Evidence Based Medicine    Clinical Article

7 Multicentric study on the beta-blocker use and relation with exacerbations in COPD Respiratory Medicine, June 19, 2014    Clinical Article

8 Fruit and vegetable intake and risk of wheezing and asthma: A systematic review and meta-analysis Nutrition Reviews, July 1, 2014    Evidence Based Medicine

9 Twice daily N-acetylcysteine 600mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): A randomised, double-blind placebo-controlled trial The Lancet Respiratory Medicine, January 30, 2014    Clinical Article

10 Chronic Cough: An Update Mayo Clinic Proceedings, October 3, 2013    Review Article    Clinical Article

11 Initial use of one or two antibiotics for critically ill patients with community-acquired pneumonia: Impact on survival and bacterial resistance Critical Care, November 8, 2013    Clinical Article

12 Regadenoson use in patients with chronic obstructive pulmonary disease: The state of current knowledge Full Text International Journal of COPD, January 23, 2014    Free full text    Review Article    Clinical Article

13 Glucocorticoid-resistant asthma Journal of Asthma, December 4, 2013    Clinical Article

14 The use of N-acetylcysteine in respiratory diseases Current Respiratory Medicine Reviews, July 17, 2014    Review Article

15 Repeated dyspnea score and percent FEV1 are modest predictors of hospitalization/relapse in patients with acute asthma exacerbation Respiratory Medicine, July 25, 2014    Clinical Article
Exclusive Author Commentary

16 A randomized study of formoterol fumarate in a porous particle metered-dose inhaler in patients with moderate-to-severe COPD Respiratory Medicine, July 10, 2014    Clinical Article

17 Effect of early versus late or no tracheostomy on mortality of critically ill patients receiving mechanical ventilation: A systematic review and meta-analysis The Lancet Respiratory Medicine, July 8, 2014    Evidence Based Medicine    Clinical Article

18 Roflumilast and dyspnea in patients with moderate to very severe chronic obstructive pulmonary disease: A pooled analysis of four clinical trials Full Text International Journal of COPD, July 28, 2014    Free full text    Clinical Article

19 Montelukast for prevention and treatment of asthma exacerbations in adults: Systematic review and meta-analysis Allergy and Asthma Proceedings, July 7, 2014    Evidence Based Medicine    Review Article

20 Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis European Respiratory Journal , July 28, 2014    Clinical Article

Indexed Journals in Pulmonology: Chest, Thorax, American Journal of Respiratory and Critical Care Medicinemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close