Chronic heart failure modifies the response to positive end-expiratory pressure in patients with chronic obstructive pulmonary disease
Journal of Critical Care,

Bihari S et al. – In subjects with severe chronic obstructive pulmonary disease (COPD) alone, caution must be used when administering positive end–expiratory pressure (PEEP) 10cm H2O or greater. Subjects with COPD+chronic heart failure (CHF) may benefit from higher levels of PEEP.

  • Positive end-expiratory pressure was administered at 0, 5, 10, 15, and 0cm H2O for 15minutes with pressure support maintained at 10cm H2O.
  • Data are expressed as mean±SD, and the effect of PEEP and differences between COPD alone and COPD + CHF were tested with repeated-measures analysis of variance.

  • Subjects were elderly (72.5±13.3years) with severe COPD (force expired volume in 1second, 1.3±0.6L; force expired volume in 1 second/force vital capacity, 40%±15%).
  • With increasing PEEP in COPD subjects, dead space ratio increased (P<.001), minute alveolar ventilation decreased (P=.001), and Paco2 increased (P=.013), with no change in COPD+CHF subjects.
  • Subjects with COPD+CHF had improvement in Pao2 and lower mean arterial pressure, whereas both were unchanged in subjects with COPD alone.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Pulmonology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pulmonology Articles

Indexed Journals in Pulmonology: Chest, Thorax, American Journal of Respiratory and Critical Care Medicinemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More