Pediatric asthma phenotypes
Current Opinion in Pediatrics,

Cowan K et al. – Heterogeneity of wheezing phenotypes may account for different responses to treatment and varied outcomes. Overlap in phenotypes and instability over time also add additional challenges to defining discrete groups of children with specific outcomes. Further studies are needed to determine combinations of variables that may improve phenotype designation with the goal of improving asthma prevention and treatment as well as predicting outcomes and understanding the pathogenesis of asthma.

Methods
  • There is currently limited ability to identify which infants and young children with recurrent wheezing will ultimately develop persistent asthma.
  • In addition, it is not clear how risk factors influence the development of asthma in later childhood and adulthood.
  • This review will discuss efforts to categorize these children with recurrent wheezing and develop asthma-predictive tools.

Results
  • Transient and persistent wheezing phenotypes have been identified with atopy, reduced lung function, and viral and bacterial respiratory infection as major risk factors for persistence of asthma.
  • Children with severe asthma tend to have greater magnitude of atopy and lower lung function than those with mild–moderate asthma.
  • These phenotypes and risk factors have been described in previous studies and are supported by the recent literature.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Pulmonology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Pulmonology Articles

1 Tadalafil in patients with chronic obstructive pulmonary disease: a randomised, double-blind, parallel-group, placebo-controlled trial The Lancet Respiratory Medicine, March 6, 2014    Clinical Article

2 Serial chitotriosidase measurements in sarcoidosis - Two to five year follow-up study Respiratory Medicine, May 30, 2014    Clinical Article

3 Azithromycin maintenance treatment in patients with frequent exacerbations of chronic obstructive pulmonary disease (COLUMBUS): A randomised, double-blind, placebo-controlled trial The Lancet Respiratory Medicine, May 15, 2014    Clinical Article

4 Multicentric study on the beta-blocker use and relation with exacerbations in COPD Respiratory Medicine, June 19, 2014    Clinical Article

5 Twice daily N-acetylcysteine 600mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): A randomised, double-blind placebo-controlled trial The Lancet Respiratory Medicine, January 30, 2014    Clinical Article

6 Efficacy and safety of once-daily fluticasone furoate/vilanterol (100/25 mcg) versus twice-daily fluticasone propionate/salmeterol (250/50 mcg) in COPD patients Respiratory Medicine, June 23, 2014    Clinical Article

7 Association of azithromycin with mortality and cardiovascular events among older patients hospitalized with pneumonia JAMA, June 4, 2014    Evidence Based Medicine    Clinical Article

8 Benefits of adding fluticasone propionate/salmeterol to tiotropium in COPD: A meta-analysis European Journal of Internal Medicine , June 17, 2014    Evidence Based Medicine    Review Article

9 Double-blind controlled trial of lecithinized superoxide dismutase in patients with idiopathic interstitial pneumonia - short term evaluation of safety and tolerability Full Text BMC Pulmonary Medicine, May 23, 2014    Free full text    Clinical Article

10 Regadenoson use in patients with chronic obstructive pulmonary disease: The state of current knowledge Full Text International Journal of COPD, January 23, 2014    Free full text    Review Article    Clinical Article

11 Inhaled beta-2-agonists/muscarinic antagonists and acute myocardial infarction in COPD patients Respiratory Medicine, June 11, 2014    Clinical Article

12 The efficacy and safety of prone positional ventilation in acute respiratory distress syndrome: Updated study-level meta-analysis of 11 randomized controlled trials Critical Care Medicine, April 18, 2014    Clinical Article

13 Tiotropium in asthma: A systematic review Full Text Journal of Asthma and Allergy, March 11, 2014    Free full text    Evidence Based Medicine    Review Article

14 Glucocorticoid-resistant asthma Journal of Asthma, December 4, 2013    Clinical Article

15 Pneumonitis and pulmonary fibrosis associated with breast cancer treatments Breast Cancer Research and Treatment, June 27, 2014    Review Article

16 Predicting survival after extracorporeal membrane oxygenation for severe acute respiratory failure: The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) Score American Journal of Respiratory and Critical Care Medicine, June 18, 2014    Clinical Article

17 The potential role of direct and indirect bronchial challenge testing to identify overtreatment of community managed asthma Clinical & Experimental Allergy, June 19, 2014    Clinical Article

18 Chronic Cough: An Update Mayo Clinic Proceedings, October 3, 2013    Review Article    Clinical Article

19 Initial use of one or two antibiotics for critically ill patients with community-acquired pneumonia: Impact on survival and bacterial resistance Critical Care, November 8, 2013    Clinical Article

20 A randomised phase II study of pemetrexed versus pemetrexed+erlotinib as second-line treatment for locally advanced or metastatic non-squamous non-small cell lung cancer European Journal of Cancer, May 22, 2014    Clinical Article

Indexed Journals in Pulmonology: Chest, Thorax, American Journal of Respiratory and Critical Care Medicinemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close