From Genotypes of Immunoglobulin Constant Heavy G Chains (FcÎ³) (GM) Genes (IGHG) to Phenotypes in Childhood Asthma
International Archives of Allergy and Immunology, 05/09/2012
Oxelius VA – Immunoglobulin heavy constant G chain (Fcγ) (GM) genes (IGHG) diplotypes present different phenotypes in childhood asthma. The IGHG2*n dose relationship to IgE sensitization and increased IgG2*n levels in IgE sensitized are risk markers for IgE–mediated asthma. The opposite IGHG2*–n presents non–IgE–mediated asthma and IgG subclass deficiencies.