The effect of aspirin in transfusion-related acute lung injury in critically ill patients

Anaesthesia, 04/19/2012

Tuinman PR et al. – The findings suggest that aspirin did not protect against transfusion–related lung injury in this cohort of critically ill patients.


  • The authors performed a post-hoc analysis of a nested case-control study that had been undertaken in a tertiary referral hospital.
  • Transfusion-related acute lung injury cases were matched with controls (transfused patients not developing lung injury).


  • Of these 218 patients, 66 used aspirin (30%).
  • Use of aspirin did not alter the risk of transfusion-related acute lung injury after transfusion of platelets (OR 1.06, CI 0.59-1.91, p=0.85), plasma (OR 1.06, 95% CI 0.59-1.92, p=0.84), or red blood cells (OR 1.09, 95% CI 0.61-1.94, p=0.77).
  • Adjustment for confounding variables using propensity scoring also did not affect the risk of acquiring transfusion-related acute lung injury (p=0.66).

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