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See Latest ArticlesCholinergic Functioning in Stimulant Addiction: Implications for Medications Development
CNS Drugs, 10/26/09
Sofuoglu M et al. – Preclinical studies support a facilitative role of nicotinic receptor agonists in the development of stimulant addiction. In contrast, nonselective muscarinic receptor agonists seem to have an inhibitory role. In human studies, acetylcholinesterase inhibitors, which increase synaptic acetylcholine levels, have shown promise for the treatment of stimulant addiction. Further studies testing the efficacy of cholinergic medications for stimulant addiction are warranted.
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