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Platelet Aggregation in Intracranial Stents May Mimic In-Stent Restenosis
American Journal of Neuroradiology, 11/02/09
Mazighi M et al. – The authors report the case of an early ISR that was due to platelet aggregation despite correct observance of a standard antiplatelet regimen. Biologic testing showed clopidogrel inefficiency, and ISR disappeared on angiography after a loading dose of clopidogrel. This result suggested that the arterial lumen reduction was due to platelet aggregation rather than in–stent myointimal hyperplasia. This observation emphasizes the importance of verifying the efficacy of clopidogrel before placing a stent.
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