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Frodl T et al. – The OFC plays a key role in the pathophysiology of major depression. The observed imbalance of OFC connectivity seems to represent a neural mechanism of the processing bias. From a neurobiological point of view, the uncoupling of precuneus and gyrus cinguli activity from the OFC might be associated with problems in the regulation of self–schemas, whereas the increased connectivity of the DLPFC to the OFC might represent a higher neural response to negative stimuli.

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