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Poldermans D et al. – Adjusting for sex, age, ankle–brachial index, cardiovascular history, time since ankle–brachial index screening, clinical factors, and medication use, both pain at rest and atypical leg symptoms were associated with comorbid mood problems. PAD patients with atypical leg symptoms or pain at rest reported more impaired mood than patients without those symptoms. These patients should be monitored closely in clinical practice, as previous research in cardiovascular patients has shown that mood disorders and sub–threshold symptoms predict poor prognosis.

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