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Primack BA – In people unable or unwilling to stop smoking abruptly, meta–analysis showed that NRT–assisted reduction–to–stop smoking resulted in sustained smoking reductions and abstinence. Meta–analysis showed that nausea was more frequent in NRT than control groups; groups did not differ for serious AEs. Nicotine replacement therapy is effective for achieving sustained smoking abstinence in smokers who do not intend or are unable to attempt an abrupt quit.

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