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The Neurobiology of Addictive Disorders
Clinical Neuropharmacology, 10/13/09

Ross S et al. – In the path from substance abuse to addiction, the neurochemistry shifts from a dopamine–based behavioral system to a predominantly glutamate–based one marked by dysregulated glutamate transmission from the prefrontal cortex to the nucleus accumbens in relation to drug versus biologically oriented stimuli. This is a core part of the executive dysfunction now understood as one of the hallmark features of addiction that also includes impaired decision making and impulse dysregulation. Understanding the neurobiology of the addictive process allows for a theoretical psychopharmacological approach to treating addictive disorders, one that takes into account biological interventions aimed at particular stages of the illness.

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Parole Revocation Among Prison Inmates With Psychiatric and Substance Use Disorders
Psychiatric Services, 11/05/09 Relevance Score: 66%

Mental Illness and Substance Use Disorders among Women Veterans with Diabetes
Women's Health Issues, 11/04/09 Relevance Score: 65%

Childhood Attention Deficit Hyperactivity Disorder, Substance Use, and Adult Functioning Among Incarcerated Women
Journal of Attention Disorders, 10/07/09 Relevance Score: 65%

Association of Race, Substance Abuse, and Health Insurance Coverage With Use of Highly Active Antiretroviral Therapy Among HIV-Infected Women, 2005
American Journal of Public Health, 11/16/09 Relevance Score: 64%

Non-treatment laboratory stress- and cue-reactivity studies are associated with decreased substance use among drug-dependent individuals
Drug and Alcohol Dependence, 10/26/09 Relevance Score: 64%