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Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression
Human Molecular Genetics, 09/24/09
Tang J et al. – Given the predominantly post–synaptic localization of dysbindin–1C and known post–synaptic effects of dysbindin–1 reductions in the rodent equivalent of the DLPFC, the present findings suggest that decreased dysbindin–1C in the DLPFC may contribute to the cognitive deficits of schizophrenia by promoting NMDA receptor hypofunction in fast–spiking interneurons.
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