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Bulut M et al. – Poor response to antipsychotics is still an important problem in the treatment of many schizophrenia patients. N–Acetylcysteine (NAC) is a compound that exerts anti–oxidant and scavenging actions against reactive oxygen species. This article reports a case of poorly responsive schizophrenia patient who improved considerably with add–on NAC 600 mg/day. The NAC might work through activating cysteine–glutamate antiporters or reducing in nitric oxide (NO) metabolites, free radicals and cytokines or through both of these mechanisms.

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