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See Latest ArticlesDuloxetine for the Treatment of Recurrent Major Depressive Disorder in Elderly Patients: Treatment Outcomes in Patients With Comorbid Arthritis
Psychosomatics, 08/19/09
Wohlreich MM et al. – The magnitude and time–course of depressive symptom improvement did not differ significantly between patients with and without arthritis. Some studies have suggested that the severity of pain in arthritis patients may be linked to depression severity.
Methods- Patients age 65 and over with recurrent MDD were stratified by arthritis status and randomized to duloxetine (a dual reuptake–inhibitor of serotonin and norepinephrine) or placebo treatment for 8 weeks (duloxetine, N=117; placebo, N=55).
- Duloxetine significantly reduced MDD symptom severity in elderly patients with and without arthritis,and produced significant reduction in several pain measures in those patients with comorbid arthritis.
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