Psychiatry Medical News about Aripiprazole treatment-resistant OCD

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Aripiprazole augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a 12-week open-label preliminary study
International Clinical Psychopharmacology, 08/13/09

Pessina E et al, – This study supports the notion that adding aripiprazole to SRIs could be a valid strategy for treatment–resistant OCD patients, and points towards the need of randomized, double–blind studies.

Methods

Patients meeting the inclusion criteria of treatment–resistant OCD entered a 12–week, open–label, flexible–dose trial of aripiprazole addition to SRIs.
Aripiprazole was started at 5 mg/day and increased up to a maximum of 20 mg/day.

Results

Twelve patients fulfilled entry criteria; nine patients took at least one dose of study medication and eight of them completed the study.
The mean daily dosage of aripiprazole in completers was 11.2±5.2 mg/day.
Patients showed a significant improvement over the 12–week study period (paired t–test for mean Yale–Brown Obsessive Compulsive Scale total score at week 12 as compared with baseline – all patients: t = 4.860, d.f. = 8, P = 0.001).
The most common adverse event reported was inner unrest reported by four (44.4%) patients.

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