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See Latest ArticlesSexual side-effects of contemporary antidepressants: review
Australian and New Zealand Journal of Psychiatry, 08/12/09
Schweitzer I et al. – There should be direct assessment of sexual function and depression using reliable, validated rating scales before and during treatment. Studies should assess treatment–emergent effects in patients with normal function and resolution of baseline dysfunction over treatment, in both the short and long term. Further research should compare available instruments for measuring sexual function, and include separate analyses of both remitters/non–remitters and male/female subjects.
Methods- Patients with major depressive disorder were identified from the literature using MEDLINE, EMBASE and PsychINFO databases.
- Bupropion and duloxetine caused significantly less sexual dysfunction than the SSRIs in short–term studies and reboxetine significantly less in both short– and longer term studies.
- Bupropion and agomelatine caused significantly less sexual dysfunction than venlafaxine.
- The evidence for mirtazepine having an advantage over the SSRIs is lacking and there are currently insufficient data for desvenlafaxine.
- Well–designed comparative studies of contemporary antidepressants with direct assessment of sexual side–effects as the primary outcome measure are scarce.
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