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See Latest ArticlesValproate and neuroprotective effects for bipolar disorder
International Review of Psychiatry, 08/11/09
Atmaca M. – It has been shown that lithium and valproate produce some changes in basal and stimulated DNA binding to activator protein 1 (AP–1) transcription factors, considering that strategic changes in gene expression in critical neuronal circuits may be important in the treatment of a variety of psychiatric disorders. So, a growing body of evidence establishes its neuroprotective and neurotrophic actions in bipolar disorder.
Methods- Neuroimaging studies that examine neurochemistry in the living brain provide further support for the hypothesis that bipolar disorder is related to changes in neuronal viability and function.
- At the genetic level, growing data suggest that the long–term treatment of mood disorders may involve the regulation of signalling pathways and gene expression in critical neuronal circuits.
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