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Smoking cessation during alcohol treatment: a randomized trial of combination nicotine patch plus nicotine gum
Addiction, 08/17/09

Cooney NL et al. – Results of this study were consistent with results of larger trials of smokers without alcohol problems, showing that combination therapy (nicotine patch plus gum) is more effective than monotherapy (nicotine patch) for smoking cessation.

Methods

Small–scale randomized double–blind placebo–controlled clinical trial with 1–year smoking and drinking outcome assessment.
Two out–patient substance abuse clinics provided a treatment platform of behavioral alcohol and smoking treatment delivered in 3 months of weekly sessions followed by three monthly booster sessions.
Participants were 96 men and women with a diagnosis of alcohol abuse or dependence and smoking 15 or more cigarettes per day.
All participants received open–label transdermal nicotine patches and were randomized to receive either 2?mg nicotine gum or placebo gum under double–blind conditions.

Results

Analysis of 1–year follow–up data revealed that patients receiving nicotine patch plus active gum had better smoking outcomes than those receiving patch plus placebo gum on measures of time to smoking relapse and prolonged abstinence at 12 months.
Alcohol outcomes were not significantly different across medication conditions.
Results of this study were consistent with results of larger trials of smokers without alcohol problems, showing that combination therapy (nicotine patch plus gum) is more effective than monotherapy (nicotine patch) for smoking cessation.

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