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Acute cognitive effects of donepezil in young, healthy volunteers
Human Psychopharmacology: Clinical and Experimental, 08/04/09

Ana LC Zaninotto ALC et al. – Positive cognitive effects of acute donepezil can be observed in various cognitive domains including mood, but its full nootropic potential is more clearly found close to theoretical peak–plasma concentration.

Methods

This was a double–blind, placebo controlled, parallel group design study of cognitive effects of acute oral donepezil (5 mg).
Subjects were tested twice after donepezil ingestion: 90 min (time that coincides with previous testing in the literature) and 210 min. (theoretical Tmax).
The test battery included tasks that tap cognitive domains that are sensitive to acetylcholine manipulations

Results

At both testing times donepezil improved long–term recall of prose, objects recall, recall of spatial locations, and integration of objects with their locations, some effects having been related to self–reported mood enhancement.
The mprovement of performance in the central executive measure (backward digit span) occurred only at Tmax.

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